Jonathan Coleman
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Phone (412) 648-4077
Fax (412) 648-9008
University of Pittsburgh
1050 Biomedical Science Tower 3
Visit Jonathan's lab website
Education & Training
Undergraduate
University of British Columbia
Hon. B.Sc. Biochemistry, 2002-2007
Postgraduate
Aarhus University, Department of Physiology
Visiting student in lab of Dr. Jens Peter Anderson, 2010
University of British Columbia, Department of Biochemistry and Molecular Biology
Ph.D. in lab of Dr. Robert Molday, 2007-2013
Oregon Health & Science University, Vollum Institute
Postdoctoral training in lab of Dr. Eric Gouaux, 2013-2020
Selected Awards and Honors
2018 OHSU School of Medicine Paper of the Month
2016 Finalist for OHSU Postdoctoral Paper of the Year
2014-2016 Banting Postdoctoral Fellowship
Representative Publications
Coleman, J.A.*, Navratna, V.*, Antermite D., Yang, D, Bull, J.A., Gouaux, E. (2020). Chemical and structural investigation of the paroxetine-human serotonin transporter complex. eLife, 9:e56427
Coleman, J.A.*, Yang, D.*, Zhao, Z., Wen, P., Yoshioka, C., Tajkhorshid, E., Gouaux, E. (2019). Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport. Nature 569, 141-145.
Coleman, J. A., Gouaux, E. (2018). Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat. Struct. Mol. Biol. 25, 170-175.
Coleman, J. A., Green, E. M., Gouaux, E. (2016). Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram. J. Vis. Exp., e54792, doi:10.3791/54792.
Coleman J.A., Green E.M., Gouaux E. (2016). X-ray structures and mechanism of the human serotonin transporter. Nature 532 (7599), 334-339.
Green E.M., Coleman J.A., Gouaux E. (2015). Thermostabilization of the human serotonin transporter in an antidepressant-bound conformation. PloS One 10 (12), e0145688.
Vestergaard A.L., Coleman J.A., Lemmin T., Mikkelsen S.A., Molday L.L., Vilsen B., Molday R.S., Dal Peraro M., Peter Andersen J. (2014). Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2. Pro. Natl. Acad. Sci. 111 (14), E1334-E1343.
Coleman J.A.*, Zhu X.*, Djajadi H.R., Molday L.L, Smith R.S., Libby R.T., John S.W.M., Molday R.S. (2014). Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. J. Cell. Sci. 127 (5), 1138-1149.
Coleman J.A., Quazi F., Molday R.S. (2013). Mammalian P(4)-ATPases and ABC transporters and their role in phospholipid transport. Biochim. Biophys. Acta. 1831, 555-74.
Coleman J.A., Vestergaard A.L., Molday R.S., Vilsen B., Peter Andersen J. (2012). Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2. Proc. Natl. Acad. Sci. 109, 1449-54.
Coleman J.A., Molday RS. (2011). Critical role of the beta-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2. J. Biol. Chem. 286, 17205-16.
Coleman J.A., Kwok M.C., Molday R.S. (2009). Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes. J. Biol. Chem. 284, 32670-9.
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