
Angela M Gronenborn
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Phone (412) 648-9959
Fax (412) 648-9008
University of Pittsburgh
1050 Biomedical Science Tower 3
Department of Structural Biology
Distinguished Professor of Structural Biology
University of Pittsburgh School of Medicine
Professor of Bioengineering
Swanson School of Engineering
Visit Angela's lab website
Education & Training
Undergraduate
University of Cologne, Cologne, Germany
Vordiplom, 1972 in Chemistry, Physics
Postgraduate
University of Cologne, Cologne, Germany
Diplom (MS), 1975 in Chemistry
University of Cologne, Cologne, Germany
Dr.rer.nat. (PhD), 1978, summa cum laude, in Organic Chemistry
National Institute for Medical Research, Mill Hill, London
Division of Molecular Pharmacology, Advisor: James Feeney
Selected Awards and Honors
2007 Elected to Membership in the National Academy of Sciences
2010 Elected to the Norwegian Academy of Science and Letters
2014 Life Science Award, Carnegie Science Awards
2014 Elected to the Germany Academy of Sciences
2018 Elected to the American Academy of Arts and Sciences
2018 ASBMB Mildred Cohn Award in Biological Chemistry
2019 Richard R. Ernst Prize in Magnetic Resonance
2020 E. Bright Wilson Award in Spectroscopy
Representative Publications
Gronenborn AM, Birdsall B, Hyde EI, Roberts GCK, Feeney J, Burgen ASV. Direct observation by NMR of two coexisting conformations of an enzyme-ligand complex in solution. Nature 230, 273 (1980).
Oschkinat H, Griesinger C, Kraulis PJ, Sørensen OW, Ernst RR, Gronenborn AM, Clore GM. Three-dimensional NMR spectroscopy of a protein in solution. Nature 332, 374 (1988).
Clore GM, Gronenborn AM. Structures of larger proteins in solution: three- and four-dimensional heteronuclear NMR spectroscopy. Science 252, 1390 (1991).
Omichinski JG, Clore GM, Schaad O, Felsenfeld G, Traino, C, Appella E, Stahl SJ, Gronenborn AM. NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science 261, 438-446 (1993).
Frank MK, Dyda F, Dobrodumov A, Gronenborn AM. Core mutations switch monomeric protein GB1 into an intertwined tetramer. Nat. Struct. Biol., 9(11): 877-885 (2002).
Byeon, IL, Meng X, Jung J, Zhao G, Yang R, Ahn J, Shi J, Concel J, Aiken C, Zhang P, Gronenborn AM. Structural convergence between Cryo-EM and NMR reveals intersubunit interactions critical for HIV-1 capsid function. Cell 139, 780 (2009). PMC2782912
Ahn J, Vu T, Novince Z, Guerrero-Santoro J, Rapic-Otrin V, Gronenborn AM. HIV-1 Vpr loads Uracil DNA Glycosylase-2 onto DCAF1, a substrate recognition subunit of a Cullin 4A-RING E3 ubiquitin ligase for proteasome-dependent degradation. J Biol Chem 285, 37333 (2010). PMC2988339
Byeon I-JL, Ahn J, Mitra, M, Byeon C-H, Hercik, K, Hritz J, Charlton LM, Levin JG, Gronenborn AM. NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity. Nature Comm 4 1890 (2013). PMC3674325
Zhao G, Perilla JR, Yufenyuy EL, Meng X, Chen B, Ning J, Ahn J, Gronenborn AM, Schulten K, Aiken C, Zhang P. Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics. Nature 497, 643 (2013). PMC3729984
Boatz JC, Whitley MJ, Li M, Gronenborn AM, van der Wel PCA. Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH. Nat Commun. 8:15137 (2017). PMC5424181
Wang M, Quinn CM, Perilla JR, Zhang H, Shirra R Jr, Hou G, Byeon IJ, Suiter CL, Ablan S, Urano E, Nitz TJ, Aiken C, Freed EO, Zhang P, Schulten K, Gronenborn AM, Polenova T. Quenching protein dynamics interferes with HIV capsid maturation. Nat Commun. 8:1779 (2017). PMC5701193
Lu M, Sarkar S, Wang M, Kraus J, Fritz M, Quinn CM, Bai S, Holmes ST, Dybowski C, Yap GPA, Struppe J, Sergeyev IV, Maas W, Gronenborn AM, Polenova T. 19F Magic Angle Spinning NMR Spectroscopy and Density Functional Theory Calculations of Fluorosubstituted Tryptophans: Integrating Experiment and Theory for Accurate Determination of Chemical Shift Tensors. J Phys Chem B.122:6148 (2018).
Active Grants
Structural Characterization of Interacting and Aggregating Cataract-associated Crystallins
09/30/19 to 07/31/23
National Institutes of Health
R01
University of Pittsburgh Center for HIV Protein Interactions (PCHPI)
08/27/2007 to 7/31/22
National Institutes of Health
P50
Allosteric regulation of SIRT1 by a PACS-2 and DBC1 regulatory hub
08/23/2017 to 6/30/21
National Institutes of Health
R01
Development of Fluorine Nuclear Magnetic Resonance (NMR) Spectroscopy as a Versatile Probe of Structure and Chemical Environment in Proteins
08/01/2017 to 7/31/21
National Science Foundation